Weill Cornell Medicine researchers from Cornell University in Ithaca have demonstrated, for the first time, that Hodgkin lymphoma cancer cells from patient samples are immune cells stuck in an "identity crisis."

Normally, a B cell matures into a plasma cell that produces antibodies to fight infection, but in this case the cells are trapped partway through the transition. They switch off key B cell features but never fully mature into functional plasma cells, instead surviving as malignant Hodgkin lymphoma cells, also called Reed-Sternberg cells.

The findings, published April 22 in Blood Cancer Journal, reframe Hodgkin lymphoma as a cancer of failed cell development, rather than simply uncontrolled growth, and suggest new diagnostic biomarkers to distinguish it from other related non-Hodgkin lymphomas.

Ithaca, NY

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